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US 11,697,841 B2Granted
Development of novel detergents for use in PCR systems
AssigneeLife Technologies Corporation
InventorsParul Angrish, Zhiwei Yang, Jonathan Wang
Life of this patent
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Abstract
This disclosure relates to novel detergents for use in various procedures including, for example, nucleic acid amplification reactions such as polymerase chain reaction (PCR). Methods for preparing the modified detergents are also described.
Claims18
A compound of Formula I:
- wherein:
- R1 is a (C8-C16) alkyl or (C8-C16) substituted alkyl;
- R2 and R3 are each independently H or CH3;
- R4 and R5 are each independently H, (CH2)nNH, (CH2)nN, or, alternatively, R3 is taken together with R5 to form a 5- or 6-membered ring which is optionally substituted with at least one (C1-C30) alkyl, (C1-C30) substituted alkyl, or (C1-C30) heteroalkyl, (C1-C30) substituted heteroalkyl;
- and
- each n is independently 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30,
- with the proviso that the compound is not one of
4 more elements
A compound of Formula I:
- wherein:
- R1 is a (C8-C16) alkyl or (C8-C16) substituted alkyl;
- R2 and R3 are each independently H or CH3;
- R4 and R5 are each independently H, (CH2)nNH, (CH2)nN, or, alternatively, R3 is taken together with R5 to form a 5- or 6-membered ring which is optionally substituted with at least one (C1-C30) alkyl, (C1-C30) substituted alkyl, or (C1-C30) heteroalkyl, (C1-C30) substituted heteroalkyl;
- and
- each n is independently 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, or 30,
- wherein when R2, R3, R4, and R5 are H, R1 is a C8 alkyl or (C8-C16) substituted alkyl, and
- wherein when R3 is taken together with R5 to form a 5-membered ring, le is a (C8-C16) substituted alkyl and/or R2 is CH3.
5 more elements
Dependencies are inferred from the claim text.