Treatment of tumor suppressor gene related diseases by inhibition of natural antisense transcript to the gene

A single-stranded synthetic, modified oligonucleotide of 15 to 27 nucleotides in length comprising at least one modification, wherein the at least one modification is selected from:

• at least one modified sugar moiety;
• at least one modified internucleotide linkage;
• at least one modified nucleotide;
• and combinations thereof;
• and further wherein said oligonucleotide is an antisense compound which is 100% complementary to and specifically hybridizes to a target region of a human natural antisense polynucleotide selected from the group consisting of SEQ ID NOs:
• 14 or 15, and wherein the oligonucleotide upregulates expression and/or function of a human PTEN gene polynucleotide having SEQ ID NO:
• 6 in vivo or in vitro as compared to a normal control oligonucleotide, wherein the target region on SEQ ID NO:
• 14 is selected from nucleotides 1-75, 137-159, 161-191, 196-301, 317-337 and 399-789 on said SEQ ID NO:
• 14.