Methods and compositions for the specific inhibition of transthyretin (TTR) by double-stranded RNA

A double stranded nucleic acid (dsNA) comprising a first oligonucleotide and a second oligonucleotide, wherein the first oligonucleotide and the second oligonucleotide form a duplex region, wherein the dsNA comprises a modified nucleotide, and wherein the dsNA sequences are selected from:

• TTR-156 Target:
• first oligonucleotide:
• (SEQ ID NO:
• 1194)
• 5’-GCAGGAUGGCUUCUCAUCGUCUGCU-3’
• second oligonucleotide:
• (SEQ ID NO:
• 426)
• 3’ -ACCGUCCUACCGAAGAGUAGCAGACGA-5’;
• TTR-242 Target:
• first oligonucleotide:
• (SEQ ID NO:
• 1211)
• 5’ -UCCAAGUGUCCUCUGAUGGUCAAAG-3’
• second oligonucleotide:
• (SEQ ID NO:
• 443)
• 3’-UUAGGUUCACAGGAGACUACCAGUUUC-5’;
• TTR-244 Target:
• first oligonucleotide:
• (SEQ ID NO:
• 1213)
• 5’-CAAGUGUCCUCUGAUGGUCAAAGUU-3’
• second oligonucleotide:
• (SEQ ID NO:
• 445)
• 3’ -AGGUUCACAGGAGACUACCAGUUUCAA-5’;
• and
• TTR-255 Target:
• first oligonucleotide:
• (SEQ ID NO:
• 1224)
• 5’-UGAUGGUCAAAGUUCUAGAUGCUGU-3’
• second oligonucleotide:
• (SEQ ID NO:
• 456)
• 3’-AGACUACCAGUUUCAAGAUCUACGACA-5’.