EPHA3 and multi-valent targeting of tumors
AssigneeWake Forest University Health Sciences
InventorsWaldemar Debinski, Carla Lema Tome, Sara Ferluga, Poonam S. Sonawane
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Abstract
Provided herein is a construct comprising, in combination: an EphA3, EphA2 and/or EphB2 binding ligand; and at least one effector molecule. In some embodiments, the at least one effector molecule comprises a therapeutic agent, a nanoparticle, a detectable group, a lipid, or a liposome. In some embodiments, the construct is a fusion protein and/or a covalent conjugate. Further provided is a construct comprising, in combination: a ligand that binds to EphA2, EphA3 and/or EphB2; a ligand that binds to IL-13Rα2; and at least one effector molecule. Also provided are methods of use thereof for treating cancer.
Claims28
A nucleic acid that encodes a polypeptide construct having a formula from N terminus to C terminus of:
- F-G-H, or H-G-F
- wherein:
- F is a ligand that binds to all three of EphA2, EphA3 and EphB2;
- G is a peptide linker;
- and H is a ligand that binds to IL-13Rα2.
A nucleic acid that encodes a polypeptide construct having a formula from N terminus to C terminus of:
- H-G-F
- wherein:
- H is a ligand that binds to IL-13Rα2;
- G is a peptide linker;
- and F is a ligand that binds to all three of EphA2, EphA3 and EphB2.
Dependencies are inferred from the claim text.