Back to results
US 11,697,671 B2Granted
Enhanced crystal nucleation
AssigneeMassachusetts Institute of Technology
InventorsKripa K. Varanasi, Henri-Louis Girard, Caroline McCue
Life of this patent
Estimating the term…
Abstract
Crystal nucleation, and associated articles, systems, and methods, are generally described.
Claims16
A composite structure, comprising:
- a particle;
- and
- a plurality of selective binding agents bound to an external surface of the particle;
- wherein:
- an areal density of the selective binding agents over the external surface of the particle is less than or equal to 100 per nm2;
- and
- the selective binding agents are capable of selectively binding to specific sites on a protein.
4 more elements
A crystallization system, comprising:
- a liquid medium comprising a solubilized crystal precursor and a plurality of particles functionalized with one or more agents;
- wherein at least one of the one or more agents is configured to selectively bind to the solubilized crystal precursor;
- wherein the crystallization system is capable of generating crystals comprising the solubilized crystal precursor when a concentration of the solubilized crystal precursor in the liquid medium is below a saturation concentration;
- and
- wherein the one or more agents are capable of selectively binding to specific sites on a protein.
2 more elements
A method, comprising:
- combining a solubilized crystal precursor with a plurality of surfaces in a liquid medium;
- and
- generating a crystal comprising the solubilized crystal precursor;
- wherein:
- the solubilized crystal precursor comprises a protein, and
- at least some of the surfaces comprise one or more agents configured to selectively bind to specific sites on the protein.
3 more elements
A method, comprising:
- combining a solubilized crystal precursor with a plurality of surfaces in a liquid medium;
- and
- generating a crystal comprising the solubilized crystal precursor;
- wherein at least some surfaces comprise one or more agents configured to selectively bind to the solubilized crystal precursor;
- and
- wherein at least a portion of the surfaces are part of an emulsified droplet.
3 more elements
Dependencies are inferred from the claim text.