Salts and polymorphs of cethromycin for the treatment of disease
AssigneeAliquantumRx, Inc.
InventorsDavid Sullivan, Amanda Hill, Kate Wittering, Amy Tapper, Nikola Kaludov
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Abstract
Disclosed herein are new salts and polymorphs of cethromycin for the treatment of diseases due to infection by bacteria and certain protozoans, including, for example, malaria, Babesosis, Toxoplasmosis, diarrheal disease, respiratory disease, sexually transmitted bacterial infections, and some bioterror bacteria, including, for example, plague, tularemia and post-inhalation anthrax. Also disclosed herein are new salts and polymorphs of cethromycin for the treatment of inflammatory diseases, including, for example, pelvic inflammatory disease, and peptic ulcer disease.
Claims21
A compound of structural Formula I
- wherein:
- a is a fractional or whole number between about 0.5 and 3.5, inclusive;
- b is a fractional or whole number between about 0 and 10, inclusive;
- and
- M is hydrochloric acid,
- wherein the compound is characterized by the presence of four or more XRPD peaks with d-spacings chosen from about 14.1, about 12.9, about 10.1, about 8.8, about 8.5, about 6.5, about 5.5, about 5.1, about 4.8, and about 4.4 Å.
Dependencies are inferred from the claim text.