C-mannoside compounds useful for the treatment of urinary tract infections
AssigneesFimbrion Therapeutics, Inc., GlaxoSmithKline Intellectual Property Development Limited
InventorsMichael Joseph Bishop, Eugene L. Stewart, Katherine Louisa Widdowson, James Walter Janetka, Laurel Kathryn McGrane
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Abstract
Disclosed herein are C-mannoside compounds, compositions thereof and their application as pharmaceuticals for the treatment of human disease. Methods of inhibition of FimH activity in a human subject are also provided for the treatment of diseases such as bacterial infection, Crohn's disease (CD) and Inflammatory Bowel Disease (IBD).
Claims20
A method of treatment of a FimH-mediated disease in a human in need thereof, comprising administering to the human a therapeutically effective amount of a compound which is:
A method of treatment of a FimH-mediated disease in a human in need thereof, comprising administering to the human a therapeutically effective amount of a compound which is:
- wherein said disease is a bacterial infection and said bacterial infection is a urinary tract infection.
Dependencies are inferred from the claim text.