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US 11,697,654 B2Granted
Kinase inhibitors exhibiting anti-cancer activity and their method of use
AssigneeAllcron Pharma Inc.
InventorsAyyappan Rajasekaran, Jon Swanson, Peter Kane, Julia Foster
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Abstract
Pharmaceutical compositions of the invention comprise kinase inhibitors having a disease-modifying action in the treatment of diseases associated with BCR-ABL activity that include cancer, including chronic myeloid leukemia, acute lymphoblastic leukemia, acute myeloid leukemia, chronic lymphocytic leukemia, multiple myeloma, lymphomas, and metastatic carcinoma.
Claims7
A compound having formula (I):
- or an enantiomer, diastereomer, tautomer or pharmaceutically acceptable salt thereof, wherein:
- R1 is selected from the group consisting of C1-6 alkyl and nitrile;
- R2 is selected from the group consisting of
- and R8 is selected from the group consisting of hydrogen, C1-6 alkyl, C1-6 haloalkyl, C3-7 branched alkyl, and C3-7 cycloalkyl.
1 more element
Dependencies are inferred from the claim text.