Polymorphic compounds and uses thereof
AssigneeNavitor Pharmaceuticals, Inc.
InventorSilvia Lenzini
Life of this patent
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Abstract
The present invention relates to compounds and methods useful for selectively modulating mTORC1 activity.
Claims20
A method of treating a disease, disorder, or condition selected from depression, treatment-resistant depression, a lysosomal storage disorder, juvenile neuronal ceroid lipofuscinosis (JNCL), cystinosis, Fabry disease, mucolipidosis type IV (MLIV), mental retardation or a genetic form of autism in a patient in need thereof,
- comprising administering to the patient in need thereof an effective amount of a crystalline form of compound A:
- or composition thereof, wherein the crystalline form is selected from the group consisting of Form A of compound A, Form B of compound A, and Form C of compound A;
- and wherein:
- Form A of compound A is characterized by peaks in its XRPD pattern at about 4.4, about 16.2, about 17.3, about 17.5, and about 17.7 degrees 2-theta;
- Form B of compound A is characterized by peaks in its XRPD pattern at about 5.0, about 6.2, about 15.2, about 17.5, and about 17.8 degrees 2-theta;
- and
- Form C of compound A is characterized by peaks in its XRPD pattern at about 7.0, about 16.1, about 16.3, about 19.3, and about 19.5 degrees 2-theta.
A method of treating treatment-resistant depression in a patient in need thereof, comprising administering to the patient in need thereof an effective amount of a crystalline form of compound A:
- or composition thereof, wherein the crystalline form is Form A of compound A;
- and wherein:
- Form A of compound A is characterized by peaks in its XRPD pattern at about 4.4, about 16.2, about 17.3, about 17.5, and about 17.7 degrees 2-theta.
Dependencies are inferred from the claim text.