Microneedle patch, micro needle system and method of fabricating the same

A microneedle patch comprising:

• a base layer including auxetic materials or a mesh structure having a negative Poisson's ratio;
• and
• a microneedle array disposed on the base layer,
• wherein:
• the microneedle array includes a plurality of microneedles each having an upper end portion and a lower end portion and which are individualized from each other;
• and
• the base layer passes the lower end portions of the microneedles neighboring each other among the plurality of microneedles, is joined to the lower end portions of the microneedles neighboring each other, and is formed of a water-soluble material.

A method of fabricating a microneedle patch, the method comprising:

• forming a base layer including a mesh structure or auxetic materials having a negative Poisson's ratio such that the base layer expands or enlarges in a direction perpendicular to an axis when a tensile force is applied in an axial direction and contracts or reduces in the direction perpendicular to the axis when a compressive force is applied in the axial direction;
• and
• forming a microneedle array on the base layer;
• wherein the base layer further includes:
• a plurality of two-dimensional re-entrant honeycomb structures which are spaced apart and stacked, a plurality of two-dimensional cut missing rib structures which are spaced apart and stacked, or mixed structures formed of a combination of the two-dimensional re-entrant honeycomb structures and the two-dimensional cut missing rib structures which are spaced apart and stacked;
• and
• interlayer connecting portions disposed between the two-dimensional re-entrant honeycomb structures which are spaced apart and stacked, disposed between the two-dimensional cut missing rib structures which are spaced apart and stacked, or disposed between the mixed structures in which the two-dimensional re-entrant honeycomb structures and the two-dimensional cut missing rib structures are spaced apart and stacked.