Degradable magnesium-based implant devices for bone fixation
AssigneeUniversity of Pittsburgh—Of the Commonwealth System of Higher Education
InventorsPrashant N. Kumta, Abhijit Roy, Da-Tren Chou, Daeho Hong, Vijay S. Gorantla
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Abstract
The invention relates to biodegradable, magnesium alloys, compositions and composites, methods for their preparation and applications for their use as implantable medical devices in load-bearing conditions. The magnesium alloys are composed of alloying elements selected from yttrium, calcium, zirconium, zinc, and strontium, with the remainder being magnesium and impurities due to production, and are prepared by melting together the elements and casting the resulting melted mixture. In certain embodiments, the methods of preparation include solution treatment and hot extrusion.
Claims2
An orthopedic or craniofacial bone fixation component composed of an extruded biodegradable, magnesium alloy, consisting of:
- from 0.5 weight percent to 4.0 weight percent of yttrium;
- from greater than zero to 1.0 weight percent of calcium;
- from 1.0 weight percent to 6.0 weight percent of zinc;
- from greater than zero to 1.0 weight percent of zirconium;
- from 0.10 weight percent to 6.0 weight percent of strontium;
- and
- a balance of magnesium and impurities due to production, based on total weight of the alloy,
- wherein the orthopedic or craniofacial bone fixation component is selected from the group consisting of Kirschner wire, cerclage wire, intramedullary rod, and intramedullary pin, and
- wherein the extruded biodegradable, magnesium alloy has formed precipitates arranged in a long period stacking order.
An orthopedic or craniofacial bone fixation component composed of an extruded biodegradable, magnesium alloy, consisting of:
- from 1.0 weight percent to 6.0 weight percent of zinc;
- from greater than zero to 1.0 weight percent of zirconium;
- optionally from greater than zero to 6.0 weight percent of strontium;
- optionally from 1.0 weight percent to 9.0 weight percent aluminum;
- optionally from 0.1 weight percent to 1.0 weight percent of manganese;
- optionally from 0.25 weight percent to 1.0 weight percent of silver;
- optionally from 0.1 weight percent to 1.0 weight percent of cerium;
- and
- a balance of magnesium and impurities due to production, based on total weight of the alloy,
- wherein the orthopedic or craniofacial bone fixation component is selected from the group consisting of Kirschner wire, cerclage wire, intramedullary rod and intramedullary pin, and
- wherein the extruded biodegradable, magnesium alloy has formed precipitates arranged in a long period stacking order.
Dependencies are inferred from the claim text.