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US 11,696,959 B2Granted
Nanoparticle-cell construct with platinum anti-cancer agent
AssigneeCity of Hope
InventorsPengpeng Cao, Jacob Berlin, Karen Aboody, Rachael Mooney, Wafa Abidi
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Abstract
The disclosure provides, inter alia, compositions including cell-nanoparticle constructs and drug loaded nanoparticles, and methods for their use in the treatment of cancer. Also provided are unmodified cisplatin molecules encapsulated by silica nanoparticles, and their use in the treatment of cancer.
Claims12
A nanoparticle-cell construct comprising an inorganic nanoparticle covalently attached to a cell surface protein through a covalent linker, wherein said cell surface protein is attached to a cell, and said covalent linker having the formula:
- -L2-X1-L1-X2-L3-;
- (Ia) or
- -L2-X2-L3-;
- (Ib)
- wherein:
- X1 and X2 are independently a bioconjugate linker or a bond, wherein at least one of X1 and X2 is a bioconjugate linker having the formula:
- L1 is a polyethylene glycol;
- L2 is selected from:
- L3 is —S—;
- wherein X2-L3 has the formula:
- wherein said nanoparticle is further covalently attached to a plurality of nanoparticle substituents, wherein said plurality of nanoparticle substituents comprises the following:
- -L2-X1—R3;
- (i) and
- -L2-X1-L1-X3;
- (ii);
- wherein
- R3 is linear polyethylene glycol with an average molecular weight of about 2000 g/mol;
- and
- X3 is
- wherein the ratio of nanoparticle substituents of the formula (i) and nanoparticle substituents of the formula (ii) is about 50:50 and L1 in formula (ii) is linear polyethylene glycol with an average molecular weight of 2000 g/mol;
- or
- wherein the ratio of nanoparticle substituents of the formula (i) and nanoparticle substituents of the formula (ii) is about 80:20 and L1 in formula (ii) is linear polyethylene glycol with an average molecular weight of about 2000 g/mol.
19 more elements
Dependencies are inferred from the claim text.