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US 11,696,953 B2Granted
Poly(beta-amino esters) and uses thereof
AssigneeMassachusetts Institute of Technology
InventorsDaniel Griffith Anderson, Kevin John Kauffman, James C. Kaczmarek, Asha Kumari Patel
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Abstract
Provided herein are branched poly(beta-amino esters) (PBAE) useful as vehicles for the delivery of therapeutic agents, such as nucleic acids. The disclosed polymers form stable compositions, and are suitable for the delivery of therapeutic agents via nebulization. Compositions of the disclosed polymers are capable of delivering therapeutic agents such as mRNA to lung epithelial cells.
Claims23
A composition comprising a poly(beta-amino ester) polymer, or a salt thereof, the polymer comprising:
- a diradical of Formula (A) having the structure:
- a diradical of Formula (B) having the structure:
- a triradical of Formula (C) having the structure:
- and
- a radical of Formula (D) having the structure:
- wherein:
- each diradical of Formula (A) has two points of attachment to radicals independently selected from Formulae (B), (C), and (D);
- each diradical of Formula (B) has two points of attachment to a diradical of Formula (A);
- each triradical of Formula (C) has three points of attachment to a diradical of Formula (A);
- and
- each radical of Formula (D) has one point of attachment to a diradical of Formula (A).
8 more elements
Dependencies are inferred from the claim text.