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US 11,696,951 B2Granted
Viscosity-reducing compounds for protein formulations
AssigneeComera Life Sciences, Inc.
InventorsPhilip Wuthrich, Robert P. Mahoney, Subhashchandra Naik, Timothy Tran, Yuhong Zeng
Life of this patent
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Abstract
The invention encompasses formulations and methods for the production thereof that permit the delivery of concentrated protein solutions. The inventive methods can yield a lower viscosity liquid protein formulation or a higher concentration of therapeutic or nontherapeutic proteins in the liquid formulation, as compared to traditional protein solutions. The inventive methods can also yield a higher stability of a liquid protein formulation.
Claims17
A liquid formulation comprising a therapeutic antibody and a viscosity-reducing amount of 1,3-dimethyluracil,
- wherein viscosity of the liquid formulation is at least about 10% less than viscosity of a control liquid formulation, wherein the liquid formulation comprises at least about 200 mg/ml of the therapeutic antibody, wherein the viscosity-reducing amount of 1,3-dimethyluracil is between about 5 mg/ml and about 30 mg/ml, and wherein the control liquid formulation comprises the therapeutic antibody and does not contain the viscosity reducing amount of 1,3-dimethyluracil.
Dependencies are inferred from the claim text.