Back to results
US 11,696,950 B2Granted
Dry solid aluminum adjuvant-containing vaccines and related methods thereof
AssigneeBoard of Regents, The University of Texas System
InventorsZhengrong Cui, Robert O. Williams, III, Xinran Li
Life of this patent
Estimating the term…
Abstract
Described herein are dry vaccine compositions and methods of freezing aluminum-containing vaccines such that when converted into a dried powder, the dry vaccine can be readily reconstituted to form a stable liquid vaccine without significant loss of activity.
Claims19
A method for preparing a thin film antigen composition comprising:
- applying a liquid solvent comprising an antigenic protein and an aluminum salt adjuvant directly to a solid freezing surface, wherein the liquid solvent is in the form of droplets at about 0.1 to 5 mm in diameter;
- and
- allowing said liquid solvent to disperse and freeze on said solid freezing surface, thereby forming a thin film antigen composition on said solid freezing surface,
- wherein the freezing rate is between 10 K/second and 103 K/second.
1 more element
Dependencies are inferred from the claim text.