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US 11,696,945 B2Granted
Proteins and immunizing compositions containing Pasteurella proteins and methods of use
AssigneeEpitopix, LLC
InventorsCharles Nelson Carver, III, Daryll Emery
Life of this patent
Estimating the term…
Abstract
The present invention provides isolated proteins isolatable from a Pasteurella spp. such as P. multocida. Also provided by the present invention are compositions that include one or more of the proteins, and methods for making and methods for using the proteins.
Claims11
A composition comprising:
- (i) an isolated protein having at least 90% similarity to amino acids 25-968 of SEQ ID NO:2, an isolated protein having at least 90% similarity to amino acids 27-790 of SEQ ID NO:4, and an isolated protein having at least 90% similarity to amino acids 23-727 of SEQ ID NO:6 or
- (ii) an isolated protein having at least 90% similarity to amino acids 25-964 of SEQ ID NO:8, an isolated protein having at least 90% similarity to amino acids 26-848 of SEQ ID NO:10, an isolated protein having at least 90% similarity to amino acids 27-784 of SEQ ID NO:12, and an isolated protein having at least 90% similarity to amino acids 25-742 of SEQ ID NO:14;
- a pharmaceutically acceptable carrier;
- and
- an adjuvant.
2 more elements
A composition comprising an isolated protein having at least 90% similarity to amino acids 26-805 of SEQ ID NO:44.
A composition comprising:
- (i) an isolated whole cell that is engineered to express at least seven proteins, wherein the seven proteins comprise a protein having at least 90% amino acid sequence identity to amino acids 25-968 of SEQ ID NO:2, a protein having at least 90% amino acid sequence identity to amino acids 27-790 of SEQ ID NO:4, a protein having at least 90% amino acid sequence identity to amino acids 23-727 of SEQ ID NO:6, a protein having at least 90% amino acid sequence identity to amino acids 25-964 of SEQ ID NO:8, a protein having at least 90% amino acid sequence identity to amino acids 26-848 of SEQ ID NO:10, a protein having at least 90% amino acid sequence identity to amino acids 27-784 of SEQ ID NO:12, and a protein having at least 90% amino acid sequence identity to amino acids 25-742 of SEQ ID NO:14, or
- (ii) two or more populations of microbes wherein each of the population expresses a subset of the seven proteins listed in (i), and the two or more populations when considered as a whole express the seven proteins.
Dependencies are inferred from the claim text.