Self-antigen specific T-cells as vaccines for augmenting engraftment and stability of autologous transfer
AssigneeVanderbilt University
InventorsRichard Thomas O'Neil, Matthew Hunter Wilson
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Abstract
Disclosed are compositions and methods relating to genetically modified cells for the long-term expression of an antigen of interest.
Claims2
A method of increasing engraftment of adoptively transferred T cells comprising administering to a subject a genetically modified T cell, wherein the T cell has been modified to express a T cell receptor specific for an antigen of interest and wherein the T cell comprises a vector encoding the antigen of interest for which the T cell receptor is specific.
A method of increasing engraftment of adoptively transferred T cells comprising administering to a subject a first T cell genetically modified to express a T cell receptor specific for an antigen of interest and a second T cell genetically modified to express a vector encoding the antigen of interest for which the T cell receptor of the first T cell is specific.
Dependencies are inferred from the claim text.