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US 11,696,941 B2Granted
Compositions comprising a PCSK9 peptide conjugated to a qbeta carrier and methods of using the same
AssigneesThe USA, as represented by the Secretary, Dept. of Health and Human Services, UNM Rainforest Innovations
InventorsAlan Remaley, John T. Schiller, Marcelo Amar, Bryce Chackerian
Life of this patent
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Abstract
A vaccine construct comprising an antigenic PCSK9 peptide and an immunogenic carrier, and methods of using the same that are effective to lower blood cholesterol levels in a mammal and treat dyslipidemias and related disease states in a mammal without the frequency of administration required by passive immunity strategies.
Claims14
A composition comprising:
- a first antigenic proprotein convertase subtilisin-kexin type 9 (PCSK9) peptide linked to a bacteriophage virus-like particle (VLP) Qbeta immunogenic carrier, the first antigenic PCSK9 antigenic peptide comprising the amino acid sequence NVPEEDGTRFHRQASKC (SEQ ID NO:3);
- and
- a second antigenic PCSK9 linked to a VLP Qbeta immunogenic carrier, the second antigenic PCSK9 peptide comprising:
- the amino acid sequence SIPWNLERIIP (amino acids 150-160 of SEQ ID NO:1), or
- the amino acid sequence SIPWNLERITP (amino acids 153-163 of SEQ ID NO:2);
- with the proviso that the composition lacks a statin or includes a statin in an amount less than is effective to lower LDL to a desired extent when administered alone.
3 more elements
Dependencies are inferred from the claim text.