Human cancer cell metastasis inhibitory agent and human cancer cell determination agent
OwnerNaofumi Miwa, Mayu Aoyamainventors
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Abstract
Provided are a novel agent for inhibiting metastasis of human cancer cells, and a novel agent for determining whether target cells are cancer cells or not in a human. A human cancer cell metastasis inhibitor including human dicalcin or a partial peptide thereof, and a human cancer cell determination agent including human dicalcin or a partial peptide thereof.
Claims4
A method of inhibiting a human cancer cell metastasis, the method including administering to a human subject an effective amount of human dicalcin or a partial peptide thereof,
- wherein the amino acid sequence of human dicalcin consists of the amino acid sequence set forth in SEQ ID NO:
- 1;
- and
- wherein the partial peptide consists of:
- an amino acid sequence selected from the group consisting of SEQ ID Nos.:
- 3, 5, 6, 7, and 8, or
- an amino acid sequence selected from the group consisting of SEQ ID Nos. 3, 5, 6, 7, and 8 with the exception that one to three amino acids are added and the partial peptide has human cancer cell metastic inhibitory activity.
A peptide which consists of one amino acid sequence selected from SEQ ID NOs:
- 5, 6, 7, and 8, and which has human cancer cell metastasis inhibitory activity,
- a peptide which consists of the same amino acid sequence as one amino acid sequence selected from SEQ ID NOs:
- 3, 5, 6, 7, and 8 except that one to three amino acids are added, and which has human cancer cell metastasis inhibitory activity, or
- a pharmaceutically acceptable salt thereof.
A peptide which consists of one amino acid sequence selected from SEQ ID NOs:
- 5, 6, 7, and 8, and which binds to a human cancer cell,
- a peptide which consists of the same amino acid sequence as one amino acid sequence selected from SEQ ID NOs:
- 3, 5, 6, 7, and 8 except that one to three amino acids are added, and which binds to a human cancer cell, or
- a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.