US 11,696,937 B2 · Glycopeptide compounds having activity of resisting drug-resistant bacteria, and preparation method and application thereof

Abstract

The present invention discloses glycopeptide compounds having activity of resisting drug-resistant bacteria, conforming to glycopeptide compounds represented by general formula (I), The present invention also provides a preparation method for and an application of the glycopeptide compounds. Upon testing, compared with a second-generation glycopeptide drug oritavancin, the glycopeptide antibiotic compounds have higher inhibition activity on drug-resistant bacterial strains, especially MRSA or VRE. Further testing shows that most of the glycopeptide compounds have safety higher than that of oritavancin and can be prepared into drugs for treating or preventing diseases caused by various bacterial infections, such as skin and soft tissue infections, meningitis, sepsis, pneumonia, arthritis, peritonitis, bronchitis, and empyema.

Claims2

Dependent claims

A glycopeptide compound having activity of resisting drug-resistant bacteria of methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE), characterized in that, conforming glycopeptide compounds shown in general formula I:

or a pharmaceutically acceptable salt thereof, wherein:
R represents by the following formula:
-A-D-E-G;
wherein:
A is a benzene ring;
D is —O— or —NH—;
E is —(CH2)m-, wherein m is 1 to 3;
G is the structural formula:
wherein L is any one of halogen, trifluoromethyl, and methoxy.

6 more elements

Dependencies are inferred from the claim text.

Facts

Application

16/978,688Filed 4 Mar 2019

Priority

CN 201810183928.66 Mar 2018

Published

US 2021/0093691 A11 Apr 2021

Granted

11 Jul 2023

Term ends

Not estimatedThe source records don’t support an estimate.

Classification11 codes

A61K 38/14
Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof: peptides containing saccharide radicals; Derivatives…
C07K 9/008
The peptide sequence being part of a ring structure: directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin,…
A61K 9/0019
Galenical forms characterised by the site of application: injectable compositions; Intramuscular, intravenous, arterial, subcutaneous…
A61K 47/02
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents…:…

Glycopeptide compounds having activity of resisting drug-resistant bacteria, and preparation method and application thereof

Life of this patent

Glycopeptide compounds having activity of resisting drug-resistant bacteria, and preparation method and application thereof

Life of this patent

Abstract

Claims2