Phosphorylcholine conjugates and uses thereof
AssigneeTpcera Ltd.
InventorsYehuda Shoenfeld, Miriam Blank
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Abstract
The present invention provides phosphorylcholine conjugates and pharmaceutical compositions comprising same for the prevention or treatment of autoimmune diseases. In particular, the conjugates of the present invention are effective in treating autoimmune diseases associated with pathological inflammation.
Claims14
A method for preventing or treating uveitis in a subject in need thereof, the method comprising administering to the subject a composition comprising at least one phosphorylcholine moiety or a derivative thereof comprising phosphorylcholine covalently bound directly to the C-terminus of an amino-acid sequence whose C-terminus consists of TKPRGY (SEQ ID NO:
- 25), and wherein
- a. said phosphorylcholine derivative is any one of 4-amino-phenyl-phosphocholine, 4-diazonio-phenyl-phosphorylcholine, 4-nitro-phenyl-phosphocholine and 12-(3-iodophenyl)dodecyl-phosphocholine;
- b. said phosphorylcholine moiety or a derivative thereof is bound to said C-terminus by an azo-bond;
- or
- c. both a and b;
- thereby preventing or treating the uveitis in the subject.
Dependencies are inferred from the claim text.