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US 11,696,928 B2Granted
Compounds and use thereof in the expansion of stem cells and/or progenitor cells
AssigneeUniversite de Montreal
InventorsBruno Simoneau, Yves Chantigny, Jonathan Yeh, Guy Sauvageau, Anne Marinier
Life of this patent
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Abstract
The invention relates to compounds as described herein and pharmaceutical compositions containing them. Also, the invention relates to methods for expanding stem cells and/or progenitor cells and methods for treating a hematopoietic disorder/malignancy, an autoimmune disease and/or an inherited immunodeficient disease.
Claims11
A method for expanding stem cells and/or progenitor cells, said method comprising contacting a starting cell population with a compound of formula I
- or a pharmaceutically acceptable salt thereof, wherein
- X is O or S;
- V1 is N or CH;
- V2 is N or CH;
- W is N or C;
- wherein not more than one of said V1, V2 and W is N;
- R1 is halo, alkyl, fluoroalkyl, cycloalkyl, alkynyl, alkenyl, cyano, or COORa, wherein Ra is an alkyl;
- R2 is H, or alkyl and R2 is absent when W is N;
- or R1 and R2 are attached together with the aromatic ring atoms to form a carbocyclic ring;
- R3 is a substituted phenyl, a substituted 5- or 6-membered heteroaryl, or
- a substituted fused bicyclic heteroaryl.
8 more elements
Dependencies are inferred from the claim text.