Methods and compositions for treatment of cancer
AssigneeWashington University
InventorsMatthew Christopher, John F. DiPersio, Timothy J. Ley, Allegra Petti, Michael P. Rettig
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Abstract
Among the various aspects of the present disclosure is the provision of methods and compositions for upregulating MHC class II in cancer cells (e.g., a hematological cancer cell). Also provided are methods of treatment for subjects suffering from hematological cancers, comprising administration of interferon-γ (IFN-γ). The methods of treatment provided herein may be particularly suitable for subjects who have received an allogenic transplant or have suffered a relapse.
Claims9
A method of upregulating an MHC class II gene of a hematological cancer cell in a subject having a hematological cancer, the method comprising administering IFN-γ to the subject, wherein the administering occurs following a post-transplantation relapse associated with downregulation of the MHC class II gene in the hematological cancer cell, and wherein the post-transplantation relapse is a relapse after a hematopoietic stem cell transplant (HCT) comprising donor T cells to the subject.
Dependencies are inferred from the claim text.