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US 11,696,922 B2Granted
Nanoparticle to target cancer
AssigneesGeorgetown University, The United States of America, as represented by the Secretary, Department of Health and Human Services
InventorsJill P. Smith, Stephan Stern, Abdullah Mahmud
Life of this patent
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Abstract
A construct, or a pharmaceutically acceptable salt thereof, comprising: (a) a polyethylene glycol-block-poly(L-lysine) polymer moiety, wherein the polyethylene glycol is thiol-functionalized; (b) a cholecystokinin-B (CCK-B) receptor ligand coupled to the polyethylene glycol of the polymer moiety; and (c) a siRNA complexed with the poly(L-lysine) of the polymer moiety, wherein the construct is neutralized.
Claims10
A method for making a construct comprising:
- (a) conjugating a maleimide-containing gastrin peptide with a block copolymer resulting in a nanoparticle, the block copolymer comprising (i) a thiol-functionalized polyethylene glycol block and (ii) a poly(L-lysine) block;
- and
- (b) mixing the resulting nanoparticle with at least one siRNA.
A method for making a construct comprising:
- (a) conjugating a cholecystokinin-B (CCK-B) receptor ligand with a block copolymer resulting in a nanoparticle, the block copolymer comprising (i) a thiol-functionalized polyethylene glycol block and (ii) a poly(L-lysine) block;
- and
- (b) mixing the resulting nanoparticle with at least one siRNA.
Dependencies are inferred from the claim text.