Viral prophylaxis treatment methods and pre-exposure prophylaxis kits
AssigneeElian LLC
InventorsEmidio A. Checcone, Christina Ramirez
Life of this patent
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Abstract
The present disclosure provides compositions and methods for the prevention of HSV infection in an HSV seronegative individual and for the treatment and prevention of recurrence in an HSV seropositive individual.
Claims46
A pharmaceutical composition for treatment of herpes simplex virus (HSV) infection, prophylaxis, or pre-exposure prophylaxis against HSV infection in a subject in need thereof comprising:
- a therapeutically effective amount of (a) valacyclovir or a salt or solvate thereof and (b) famciclovir or a salt or solvate thereof;
- and pharmaceutically acceptable excipient(s), diluent(s), carrier(s) and/or adjuvant(s).
A method of pre-exposure prophylaxis against HSV infection in an HSV seronegative subject in need thereof, or a method of treating an HSV infection, or a method of suppressing an HSV infection, or a method of treatment or prophylactic treatment of a disease or condition associated with HSV infection, the method comprising administering to the subject daily a therapeutically effective amount of (a) valacyclovir or a salt or solvate thereof and (b) famciclovir or a salt or solvate thereof;
- and pharmaceutically acceptable excipient(s), diluent(s), carrier(s) and/or adjuvant(s).
A method of pre-exposure prophylaxis against herpes simplex virus (HSV) infection in an HSV seronegative subject in need thereof, or a method of treating an HSV infection, or a method of suppressing an HSV infection, or a method of treatment or prophylactic treatment of a disease or condition associated with HSV infection, the method comprising administering to the subject daily a therapeutically effective amount of greater than 100 mg/kg body weight of an antiviral agent comprising acyclovir or a salt or solvate thereof, or valacyclovir or a salt or solvate thereof, or famciclovir or a salt or solvate thereof, or combinations thereof, whereby the risk of HSV infection in the subject is reduced.
Dependencies are inferred from the claim text.