Compositions and methods of use of phorbol esters
AssigneeBiosuccess Biotech Co. Ltd.
InventorsZheng Tao Han, Hung-Fong Chen
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Abstract
Methods and compositions containing a phorbol ester or a derivative of a phorbol ester are provided for the treatment of chronic and acute conditions. Such conditions may be caused by disease, be symptoms or sequelae of disease. Chronic and acute conditions may be due to viral infections such as HIV and AIDS, neoplastic diseases stroke, kidney disease, urinary incontinence, autoimmune disorders, Parkinson's disease, prostate hypertrophy, aging, or the treatment of such diseases. Additional compositions and methods are provided which employ a phorbol ester or derivative compound in combination with at least one additional agent to yield more effective treatment tools against acute and chronic conditions in mammalian subjects.
Claims11
A method for treating or alleviating one or more symptoms of Parkinson's disease in a mammalian subject comprising administering an effective amount of from 10 μg to 1500 μg of a phorbol ester of Formula I, or a pharmaceutically-acceptable salt, isomer, enantiomer, solvate, hydrate, or polymorph thereof to said subject,
- wherein R1 and R2 are selected from the group consisting of hydrogen, hydroxyl,
- wherein the alkyl group contains 1 to 15 carbon atoms,
- wherein the lower alkenyl group contains 1 to 7 carbon atoms,
- and R3 is hydrogen or
- wherein the one or more symptoms of Parkinson's disease is tremor at rest, stiffness, bradykinesia, rigidity, speech impairment, cognitive impairment, dementia, mood impairment, drowsiness, insomnia and postural instability.
Dependencies are inferred from the claim text.