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US 11,696,747 B2Granted
Devices and methods for semen analysis
AssigneeNanovare SAS
InventorsDaniel Thomas, Mohamed Hamza, Fanny Chesa
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Abstract
Provided herein are devices and methods for analysis of male fertility. The invention provides self-contained, hand-held receptacles and systems for collection and analysis of semen samples and methods of using such devices to analyze semen samples. Also provided are processor-implemented and machine learning methods of analyzing semen sample data obtained using devices of the invention.
Claims14
A system for analysis of a semen sample, the device comprising:
- a receptacle for collection of the semen sample, the receptacle having an opening that can accommodate at least a tip of a penis;
- a microfluidic element in fluidic communication with the receptacle;
- an analytical device comprising an optical device positioned to interrogate a portion of the semen sample in the microfluidic element;
- and
- a processor configured to receive optical data from the optical device and determine sperm number, sperm morphology, and sperm motility of the semen sample, wherein determination of sperm morphology comprises an optical analysis of one or more of head size, head shape, midpiece shape, midpiece size, tail shape, tail size, duplicate forms, and cytoplasmic droplets.
2 more elements
A method of analyzing a semen sample from a subject, the method comprising:
- providing a device comprising:
- a receptacle for collection of the semen sample, the receptacle having an opening that can accommodate at least a tip of a penis;
- a microfluidic element in fluidic communication with the receptacle;
- an analytical device comprising an optical element positioned to interrogate a portion of the semen sample in the microfluidic element;
- and
- a processor;
- receiving a semen sample into the receptacle directly from the tip of the penis;
- and
- automatically determining, via the optical element and processor, sperm number, sperm morphology, and sperm motility information of the semen sample within the device, wherein the method is performed without any external sample preparation steps and the sperm morphology information comprises one or more of head size, head shape, midpiece shape, midpiece size, tail shape, tail size, duplicate forms, and cytoplasmic droplets.
6 more elements
Dependencies are inferred from the claim text.