Assessment of iron deposition post myocardial infarction as a marker of myocardial hemorrhage
AssigneeCedars-Sinai Medical Center
InventorsRohan Dharmakumar, Ivan Cokic
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Abstract
The invention is directed to methods for diagnosing reperfusion/non-reperfusion hemorrhage and predicting cardiac arrhythmias and sudden cardiac death in subjects comprising using imaging techniques to detect regional iron oxide deposition. The invention also provides treatment methods for subject at increased risk of sudden cardiac death.
Claims19
A method for treating a subject at an increased risk of sudden cardiac death associated with having regional iron deposition in the heart comprising:
- administering to the subject, at least in chronic phase of a myocardial infarction (MI), an effective amount of a composition comprising a chelating agent, based on knowledge of an increase in iron oxide deposition in the chronic phase in the infarcted region relative to a remote region following reperfusion hemorrhage, so as to treating the subject at an increased risk of sudden cardiac death associated with regional iron deposition in the heart,
- wherein the subject has been detected to have an increase in iron oxide deposition in a hemorrhagic infarcted region of the subject's heart relative to the remote region of the subject's heart.
A method for treating a subject with localized iron-containing deposits in myocardial tissue, or associated electrical conduction abnormalities and/or mechanical abnormalities in myocardium, comprising:
- administering, at least in chronic phase of myocardial infarction (MI), an effective amount of a composition comprising a chelating agent to the subject, based on knowledge of an increase in iron oxide deposition in the chronic phase in the infarcted region relative to a remote region following reperfusion hemorrhage, so as to treat the subject with localized iron-containing deposits in the myocardial tissue or associated electrical conduction abnormalities and/or mechanical abnormalities in myocardium,
- wherein the subject has been detected to have an increase in iron oxide deposition in a hemorrhagic infarcted region of the subject's heart relative to the remote region of the subject's heart.
A method for reducing myocardial inflammation in a subject in need thereof comprising:
- selecting a subject with regional iron oxide deposits or deposits containing iron in the heart;
- and
- administering, at least in chronic phase of myocardial infarction (MI), an effective amount of a composition comprising a chelating agent to the subject, based on knowledge of an increase in iron oxide deposition in the chronic phase in the infarcted region relative to a remote region following reperfusion hemorrhage, so as to reduce myocardial inflammation in the subject,
- wherein the subject has been detected to have an increase in iron oxide deposition in a hemorrhagic infarcted region of the subject's heart relative to the remote region of the subject's heart.
Dependencies are inferred from the claim text.