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US 11,696,594 B2Granted
Vitamin formulation
AssigneeDsm IP Assets B.V.
InventorsBernd Schlegel, Loni Schweikert, Olivia Vidoni
Life of this patent
Estimating the term…
Abstract
The present patent application relates to solid particles comprising at least one fatsoluble vitamin, which are more stable when compressed into tablets.
Claims4
A compressed tablet consisting of:
- (a) about 24.48 wt. %, based on total weight of the compressed table, of solid particles;
- (b) about 30.14 wt. %, based on total weight of the compressed tablet, of microcrystalline cellulose,
- (c) about 45.20 wt. %, based on total weight of the compressed tablet, of calcium phosphate, and
- (d) about 0.18 wt. %, based on total weight of the compressed tablet, of magnesium stearate, wherein
- the solid particles consist of, based on the total weight of the solid particles, of:
- (i) 27.00 wt. % of vitamin A acetate,
- (ii) 0.75 wt. % of dl-α-tocopherol;
- (iii) 0.75 wt. % of butylated hydroxytoluene (BHT);
- (iii) 47.31 wt. % of food modified starch;
- (iv) 18.19 wt. % of trehalose as a non-reducing sugar;
- (v) 4.00 wt. % of corn starch;
- and
- (vi) 2.00 wt. % of water, wherein
- the compressed tablet is a compression product of compressing the components (a)-(d) at a pressure between 5-40 kN, and wherein
- the compressed tablet has greater retention of the vitamin A acetate as compared to a similar compressed tablet that does not contain the trehalose after storage in a closed brown-glass bottle at room temperature for 35 days.
12 more elements
Dependencies are inferred from the claim text.