Generator columns for elution systems loaded with pre-charged matrix
AssigneeJubilant Draximage Inc.
InventorRobert William Riddoch
Life of this patent
Estimating the term…
Abstract
The present disclosure relates in general to nuclear medicine and generators for the production of radiopharmaceuticals for medical use. In particular, present disclosure relates to a generator column that resists high heat such as depyrogenation and sterilization. This allows some steps of the preparation of the column to be performed in a non-sterile environment. This also allows the generator column to be reusable. The present disclosure further describes methods for the preparation of a generator where a parent radioisotope is charged on the column matrix before or after the matrix is loaded in the column.
Claims20
A generator column of an elution system for the elution of a radioactive solution, wherein the column is prepared by the following steps:
- a) a pre-loading step that is performed prior to loading the column with charged matrix, which comprises loading the column partially with a particulate ion exchange matrix at about 50% to 85% of the total capacity of the column that is not charged with a parent radioisotope;
- b) performing the completion of column loading by charging the remaining amount of matrix with the parent radioisotope outside the column;
- and
- c) loading the charged matrix in the column.
A generator column of an elution system for the elution of a radioactive solution, wherein the column is cleaned following use by a process comprising the following steps:
- a) emptying the used column by removing the used matrix therefrom;
- b) optionally, sterilizing the empty column resulting from step (a);
- c) loading a new particulate ion exchange matrix into the sterilized column resulting from step (b);
- d) charging a parent radioisotope on the particulate ion exchange matrix of step (c), and
- e) sterilizing e charge column.
Dependencies are inferred from the claim text.