Systems and methods for mapping neuronal circuitry and clinical applications thereof

A system for virtually testing treatment using a neuronal shape graph, comprising:

• at least one processor;
• and
• at least one memory, comprising a neuronal mapping application, where the neuronal mapping application directs the processor to:
• obtain functional brain imaging data from an imaging device, where the functional brain imaging data comprises a time-series of voxels describing neuronal activation over time in a patient's brain;
• lower the dimensionality of the functional brain imaging data to a set of points, where each point represents the brain state at a particular time in the time-series;
• bin the points into a plurality of bins;
• cluster the binned points;
• and
• generate a shape graph from the clustered points, where nodes in the shape graph represent a brain state and edges between the nodes represent transitions between brain states;
• generate a virtual brain using the shape graph such that the virtual brain simulates the patient's brain;
• virtually treat the virtual brain;
• generate a second shape graph using the treated virtual brain;
• and
• determine a treatment efficacy based on the second shape graph.