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US 11,693,010 B2Granted
Method of characterization of visible and/or sub-visible particles in biologics
AssigneeRegeneron Pharmaceuticals, Inc.
InventorXiaobin Xu
Life of this patent
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Abstract
A method for characterizing or quantifying one or more proteins in visible and/or sub-visible particles formed in a sample by detecting the at least one visible or sub-visible particle in the sample, isolating and capturing the at least one visible or sub-visible particle to identify a presence of a protein, and using a mass spectrometer to characterize the protein.
Claims14
A method for identification of a host cell-protein in at least one visible or sub-visible particle in a sample, comprising:
- isolating and capturing the at least one visible or sub-visible particle;
- analyzing the at least one visible or sub-visible particle to identify a presence of a protein using Raman spectroscopy;
- and
- subjecting the at least one visible or sub-visible particle to liquid chromatography separation coupled to a mass spectrometer to identify the host cell protein.
1 more element
Dependencies are inferred from the claim text.