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AssigneeHMI Medical Innovations, LLC
InventorsGerard M Housey, Monica E. Balash
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This invention relates to methods of identifying, synthesizing, optimizing and profiling compounds that are inhibitors or activators of proteins, both naturally occurring endogenous proteins as well as certain variant forms of endogenous proteins, and novel methods of identifying such variants. The method accelerates the identification and development of compounds as potential therapeutically effective drugs by simplifying the pharmaceutical discovery and creation process through improvements in hit identification, lead optimization, biological profiling, and rapid elimination of toxic compounds. Implementation results in overall cost reductions in the drug discovery process resulting from the corresponding increases in efficiency.
A method of treating a condition in a human subject, comprising administering to the human subject a therapeutically effective amount of a compound, the compound capable of modulating a target protein in the human subject, wherein a cellular phenoresponse is linked to the presence and functional activity of the target protein, the target protein being associated with the condition, the condition being relapsing neoplastic disorders and proliferative disorders, including leukemia, the compound being selected for modulating the target protein using a method of identifying improved cellular specificity as compared to a known modulator of the target protein, comprising:
Dependencies are inferred from the claim text.