Quality control reagents and methods
AssigneePromega Corporation
InventorsJoshua Jacques Coon, Michael M. Rosenblatt, Marjeta Urh
Life of this patent
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Abstract
The present invention provides reagents for instrumentation quality control and methods of use thereof. In particular, sets of peptides or other molecules are provided for evaluating the performance of instruments with mass spectrometry (MS) and/or liquid chromatography (LC) functionalities.
Claims20
A peptide mixture comprising three or more distinct-mass versions of each of three or more distinct-sequence peptides, wherein two or more of the distinct-mass versions of each distinct-sequence peptide comprises one or more amino acids with above natural-abundance levels of one or more heavy isotopes, and wherein the distinct-sequence peptides:
- do not contain one or more of tryptophan, methionine, cysteine, proline, asparagine, glutamine, or histidine residues;
- and/or
- do not contain internal lysine or arginine residues.
Dependencies are inferred from the claim text.