Affinity reagents having enhanced binding and detection characteristics

A detectable probe, comprising:

• (a) a retaining component comprising nucleic acid origami, wherein the nucleic acid origami comprises a scaffold nucleic acid and a staple nucleic acid hybridized to two regions of the scaffold nucleic acid, wherein the two regions of the scaffold nucleic acid are separated by an intervening region that does not hybridize to the staple nucleic acid;
• (b) a label component attached to the retaining component;
• and
• (c) two or more binding components attached to the retaining component, wherein the two or more binding components have the same binding specificity for an epitope of a binding partner, and wherein at least one of the two or more binding components is bound to the epitope of the binding partner via non-covalent binding,
• wherein the binding partner is attached to an array of different binding partners at a site that is physically isolated from all other binding partners in the array, and wherein the detectable probe is smaller than the site.