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US 11,692,214 B2Granted
Barcoded beads and method for making the same by split-pool synthesis
AssigneeRoche Sequencing Solutions, Inc.
InventorGarry P. Nolan
Life of this patent
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Abstract
The invention provides methods, compositions, kits and devices for the detection of target molecules. In some embodiments, the invention allows for multiplexed target molecule detection.
Claims26
A population of beads, comprising:
- (a) a first bead associated with a first nucleic acid tag that comprises:
- (i) a first cell origination barcode;
- and
- (ii) a degenerate sequence;
- and
- (b) a second bead associated with a second nucleic acid tag that comprises:
- (i) a second cell origination barcode, and
- (ii) a degenerate sequence;
- wherein the first and second cell origination barcodes are different.
6 more elements
A method for making a population of barcoded beads, comprising:
- adding nucleic acid tags that comprise a cell origination barcode and a degenerate sequence onto beads by a split-pool barcoding process.
Dependencies are inferred from the claim text.