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US 11,692,191 B2Granted
Method for separating, capturing, analyzing and retrieving cells and cell products by using microstructure
AssigneeSeoul National University R&Db Foundation
InventorsSung Hoon Kwon, Jun Hoi Kim, Seo Hee Chang, Ok Ju Kim
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Abstract
The present invention relates to a technique for genomic library screening and provides a method for separating, capturing, analyzing, and retrieving cells and cell products by using a microstructure that can be preferentially applied to the field of antibody engineering for the development of new therapeutic antibodies and can be extensively applied to multiple genetic/phenotypic analysis of various biochemical molecules, for example, in the field of protein engineering and metabolic engineering.
Claims21
A biological sample analysis chip comprising:
- a microstructure-based analysis chip;
- a substrate-based analysis chip;
- and
- an array of microreaction chambers defined by the microstructure-based analysis chip and the substrate-based analysis chip,
- wherein at least one of the microstructure-based analysis chip and the substrate-based analysis chip is configured to capture library-carrying cells and/or library-carrying cell products formed by biochemical reactions of the cells,
- the microstructure-based analysis chip and the substrate-based analysis chip are detachable from each other and separately analyzable, and
- the biological sample analysis chip further comprises an energy-absorbing layer, wherein the energy-absorbing layer is configured such that target samples located on sites of the energy-absorbing layer to which energy is applied;
- are separated from the microstructure-based analysis chip or the substrate-based analysis chip upon the energy application.
5 more elements
Dependencies are inferred from the claim text.