Xylose isomerases that confer efficient xylose fermentation capability to yeast
AssigneesVib Vzw, Katholieke Universiteit Leuven, KU LEUVEN R&D, GlobalYeast N.V.
InventorsJohan Thevelein, Mekonnen Demeke, Maria Remedios Foulquié Moreno, Stijn De Graeve, Edgard Valdomiro Charles Belo
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Abstract
The present invention relates to novel nucleic acid sequences encoding bacterial xylose isomerases that upon transformation of a eukaryotic microbial host cell, such as yeast, to confer to the host cell the ability of isomerising xylose to xylulose. The nucleic acid sequences encode xylose isomerases that originate from bacteria such as Eubacterium sp., Clostridium cellulosi and others. The invention further relates to fermentation processes wherein the transformed host cells ferment a xylose-containing medium to produce ethanol or other fermentation products.
Claims12
A genetically engineered fungal cell that is able to grow on xylose as a sole carbon source, wherein the fungal cell comprises a polynucleotide encoding a xylose isomerase having at least 95% sequence identity with SEQ ID NO:
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Dependencies are inferred from the claim text.