Anti-CD40L antibodies and methods for treating CD40L-related diseases or disorders
AssigneeALS Therapy Development Institute
InventorsJohn M. Lincecum, Bingbing Jiang, Steven N. Perrin, Alan Gill, Cynthia A. Gill, Fernando G. Vieira
Life of this patent
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Abstract
Anti-human CD40L antibodies engineered to lack the ability to activate platelets and methods for treating patients having a CD40L-associated disease.
Claims8
A method for treating a subject with a CD40L associated disease or disorder comprising administering to the subject a therapeutically effective amount of an isolated antibody wherein the antibody binds to CD40L and comprises a light and a heavy chain, wherein
- (i) the light chain consists of the amino acid sequence of SEQ ID NO:7;
- and the heavy chain consists off the amino acid sequence of SEQ ID NO:9;
- or
- (ii) the light chain consists of the amino acid sequence of SEQ ID NO:7;
- and the heavy chain consists of the amino acid sequence of SEE ID NO:
- 13;
- or
- (iii) the light chain consists of the amino acid sequence of SEQ ID NO:
- 11;
- and the heavy chain consists of the amino add sequence of SEQ ID NO:9;
- or
- (iv) the light chain consists of the amino acid sequence of SEQ ID NO:
- 11;
- and the heavy chain consists of the amino add sequence of SEQ ID NO:13;
- wherein the light chain comprises the CDR1 of SEQ ID NO:
- 15;
- wherein the light chain comprises the CDR2 of SEQ ID NO:
- 16;
- wherein the light chain comprises the CDR3 of SEQ ID NO:
- 17;
- wherein the heavy chain comprises the CDR1 of SEQ ID NO:
- 18;
- wherein the heavy chain comprises the CDR2 of SEQ ID NO:
- 19;
- wherein the heavy chain comprises the CDR3 of SEQ ID NO:
- 20;
- wherein the disease or disorder is a neurodegenerative or neuromuscular disease or disorder;
- an inflammatory or immune disease or disorder;
- or an autoimmune disease.
A method of inhibiting an immune response in a subject comprising administering to the subject a therapeutically effective amount of an isolated antibody wherein the antibody binds to CD40L and comprises a light and a heavy chain, wherein
- (i) the light chain consists of the amino acid sequence of SEQ ID NO:7;
- and the heavy chain consists of the amino acid sequence of SEQ ID NO:9;
- or
- (ii) the light chain consists of the amino acid sequence of SEQ ID NO:7;
- and the heavy chain consists of the amino acid sequence of SEQ ID NO:13;
- or
- (iii) the light chain consists of the amino acid sequence of SEO ID NO:11;
- and the heavy chain consists of the amino acid sequence of SEO ID NO:9;
- or
- (iv) the light chain consists of the amino acid sequence of SEO ID NO:
- 11;
- and the heavy chain consists of the amino acid sequence of SEO [D NO:
- 13;
- and the immune response is graft vs. host disease or organ transplant rejection.
Dependencies are inferred from the claim text.