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US 11,692,035 B2Granted
Therapeutic CD47 antibodies
AssigneeArch Oncology, Inc.
InventorsPamela T. Manning, Robyn Puro, Juan C. Almagro, Robert W. Karr
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Abstract
Provided are anti-CD47 monoclonal antibodies (anti-CD47 mAbs) with distinct functional profiles as described herein, methods to generate anti-CD47 mAbs, and to methods of using these anti-CD47 mAbs as therapeutics for the prevention and treatment of solid and hematological cancers, ischemia-reperfusion injury, cardiovascular diseases, autoimmune diseases, inflammatory diseases or as diagnostics for determining the level of CD47 in tissue samples.
Claims17
A method of treating cancer in a human subject, the method comprising:
- administering to the human subject a monoclonal antibody or an antigen binding fragment thereof,
- wherein the monoclonal antibody or an antigen binding fragment thereof
- a) binds to human CD47 on the surface of a tumor cell;
- b) blocks SIRPα binding to human CD47;
- c) increases phagocytosis of human tumor cells;
- and
- d) induces death of human tumor cells;
- and
- wherein the monoclonal antibody or antigen binding fragment thereof comprises a combination of a heavy chain variable domain (VH) and a light chain variable domain (VL) selected from the group consisting of:
- (i) a VH domain comprising the amino acid sequence of SEQ ID NO:
- 38 and a VL domain comprising the amino acid sequence of SEQ ID NO:
- 51;
- (ii) a VH domain comprising the amino acid sequence of SEQ ID NO:
- 39 and a VL domain comprising the amino acid sequence of SEQ ID NO:
- 51;
- (iii) a VH domain comprising the amino acid sequence of SEQ ID NO:
- 40 and a VL domain comprising the amino acid sequence of SEQ ID NO:
- 51;
- (iv) a VH domain comprising the amino acid sequence of SEQ ID NO:
- 36 and a VL domain comprising the amino acid sequence of SEQ ID NO:
- 52;
- (v) a VH domain comprising the amino acid sequence of SEQ ID NO:
- 38 and a VL domain comprising the amino acid sequence of SEQ ID NO:
- 52;
- (vi) a VH domain comprising the amino acid sequence of SEQ ID NO:
- 39 and a VL domain comprising the amino acid sequence of SEQ ID NO:
- 52;
- and
- (vii) a VH domain comprising the amino acid sequence of SEQ ID NO:
- 40 and a VL domain comprising the amino acid sequence of SEQ ID NO:
- 52.
28 more elements
Dependencies are inferred from the claim text.