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US 11,692,032 B2Granted
Anti-LAG3 antibodies and uses thereof
AssigneeRegeneron Pharmaceuticals, Inc.
InventorsErica Ullman, Aynur Hermann, Ella Ioffe, Elena Burova, Gavin Thurston
Life of this patent
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Abstract
The present invention provides antibodies that bind to the T cell co-inhibitor lymphocyte activation gene 3 (LAG3) protein, and methods of use. In various embodiments of the invention, the antibodies are fully human antibodies that specifically bind to LAG3. In some embodiments, the antibodies of the invention are useful for inhibiting or neutralizing LAG3 activity, thus providing a means of treating a disease or disorder such as cancer or viral infection.
Claims28
A set of polynucleotide molecules comprising:
- a first polynucleotide molecule comprising polynucleotide sequences encoding three heavy chain complementarity determining regions (HCDRs) (HCDR1, HCDR2, and HCDR3) within a heavy chain variable region (HCVR) of an antibody that binds specifically to human lymphocyte activation gene 3 (LAG3) protein, wherein the first polynucleotide molecule comprises a polynucleotide sequence of an HCDR1 as set forth in SEQ ID NO:
- 419, a polynucleotide sequence of an HCDR2 as set forth in SEQ ID NO:
- 421, and a polynucleotide sequence of an HCDR3 as set forth in SEQ ID NO:
- 423.
1 more element
A set of polynucleotide molecules comprising:
- a first isolated polynucleotide molecule comprising a polynucleotide sequence that encodes a heavy chain variable region (HCVR) of an antibody that binds specifically to human lymphocyte activation gene 3 (LAG3) protein, wherein the HCVR comprises:
- a heavy chain complementarity determining region (HCDR1) encoded by a polynucleotide sequence as set forth in SEQ ID NO:
- 419, a heavy chain complementarity determining region 2 (HCDR2) encoded by a polynucleotide sequence as set forth in SEQ ID NO:
- 421, and a heavy chain complementarity determining region 3 (HCDR3) encoded by a polynucleotide sequence as set forth in SEQ ID NO:
- 423.
2 more elements
Dependencies are inferred from the claim text.