Antibody constructs for CLDN18.2 and CD3

An antibody construct comprising a first domain which binds Claudin 18.2 (CLDN18.2), and a second domain which binds human CD3, wherein the first domain comprises a VH region comprising CDR-H1, CDR-H2 and CDR-H3 and a VL region comprising CDR-L1, CDR-L2 and CDR-L3 selected from the group consisting of:

• a) CDR-H1 as depicted in SEQ ID NO:
• 121, CDR-H2 as depicted in SEQ ID NO:
• 122, and CDR-H3 as depicted in SEQ ID NO:
• 123, CDR-L1 as depicted in SEQ ID NO:
• 124, CDR-L2 as depicted in SEQ ID NO:
• 125 and CDR-L3 as depicted in SEQ ID NO:
• 126;
• and
• b) CDR-H1 as depicted in SEQ ID NO:
• 133, CDR-H2 as depicted in SEQ ID NO:
• 134, and CDR-H3 as depicted in SEQ ID NO:
• 135, and CDR-L1 as depicted in SEQ ID NO:
• 136, CDR-L2 as depicted in SEQ ID NO:
• 137 and CDR-L3 as depicted in SEQ ID NO:
• 138.