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US 11,692,026 B2Granted
Antibodies to PfGARP kill Plasmodium falciparum malaria parasites and protect against infection and severe disease
AssigneeRhode Island Hospital
InventorsJonathan Kurtis, Dipak K. Raj, Alok Das Mohapatra, Jenna Zuromski
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Abstract
Provided herein are methods, compositions and kits for preventing and treating malaria. Also included herein are kits for preventing and treating malaria.
Claims12
A recombinant, humanized, anti-Plasmodium falciparum (P. falciparum) PfGARP antibody comprising a heavy chain variable region comprising the amino acid sequences set forth in SEQ ID NO:
- 13 (complementary determining region (CDR)1), SEQ ID NO:
- 2 (CDR2), and SEQ ID NO:
- 3 (CDR3);
- and a light chain variable region comprising the amino acid sequences set forth in SEQ ID NO:
- 4 (CDR1), SEQ ID NO:
- 5 (CDR2), and SEQ ID NO:
- 6 (CDR3).
4 more elements
Dependencies are inferred from the claim text.