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US 11,692,023 B2Granted
Human zika virus antibodies and methods of use therefor
AssigneeVanderbilt University
InventorJames E. Crowe, Jr.
Life of this patent
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Abstract
The present disclosure is directed to antibodies binding to and neutralizing Zika virus and methods for use thereof.
Claims14
An isolated monoclonal antibody that specifically binds to Zika virus E protein, comprising heavy chain CDR sequences SEQ ID NO:
- 266;
- 267 and 268;
- and light chain CDR sequences SEQ ID NO:269;
- GAS;
- and SEQ ID NO:270;
- wherein the antibody comprises a mutagenized Fc variant sequence exhibiting reduced FcR interactions.
3 more elements
An isolated monoclonal antibody fragment that specifically binds to Zika virus E protein, comprising heavy chain CDR sequences SEQ ID NO:
- 266;
- 267 and 268;
- and light chain CDR sequences SEQ ID NO:269;
- GAS;
- and SEQ ID NO:270, wherein the fragment is a single chain fragment variable (scFv) antibody, an Fab fragment, an F(ab′)2 fragment, or an Fv fragment.
2 more elements
Dependencies are inferred from the claim text.