General amyloid interaction motif (GAIM)

A polypeptide comprising a variant of starting amino acid sequence SEQ ID NO:16, wherein the variant differs from SEQ ID NO:16 by one or more sets of amino acid changes selected from:

• a) substitution of T50 with any amino acid and H55T;
• b) N137G;
• c) N142A;
• d) R143V and Q144N;
• or
• R143V, Q144N, and A146V;
• or
• R143V, Q144N, and A146T;
• or
• R143V, Q144N, and A146K;
• and
• e) Q156V, G157N, ΔT158, ΔD159, ΔP160, and V161G;
• or
• Q156Y, G157N, ΔT158, ΔD159, ΔP160, and V161G;
• or
• G157N, ΔT158, ΔD159, ΔP160, and V161G;
• or
• ΔT158, ΔD159, ΔP160, and V161G;
• wherein the variant optionally further differs from SEQ ID NO:16 by one or more sets of amino acid changes selected from:
• f) ΔM1;
• or
• ΔM1 and ΔA2;
• and
• g) substitution of N38 with any amino acid other than cysteine;
• or
• substitution of N38 with any amino acid other than cysteine, and substitution of G40 with any amino acid other than cysteine;
• or
• substitution of G40 with any amino acid other than cysteine, threonine, or serine.