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US 11,692,012 B2Granted
Human cytomegalovirus comprising exogenous antigens
AssigneeOregon Health & Science University
InventorsKlaus Frueh, Scott G. Hansen, Jay Nelson, Louis Picker, Patrizia Caposio
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Abstract
Human cytomegalovirus vectors comprising heterologous antigens are disclosed. The vectors derived from the TR strain, are ganciclovir sensitive, include active US2, US3, US6, US7 and UL131A genes, and have a deleterious or inactivating mutation in the UL82 gene preventing the expression of pp71.
Claims30
A recombinant human cytomegalovirus (HCMV) comprising:
- (1) a first nucleic acid encoding at least one heterologous antigen;
- (2) an inactivating mutation in the UL45 gene;
- and
- (3) active US2, US3, US6, US7, UL97, and UL131A genes;
- wherein the recombinant HCMV is a genetically modified TR strain of HCMV;
- and the recombinant HCMV is ganciclovir-sensitive.
3 more elements
Dependencies are inferred from the claim text.