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US 11,692,009 B2Granted
IL-2alpha receptor subunit binding compounds
AssigneeMedikine, Inc.
InventorsWilliam J. Dower, Michael C. Needels, Ronald W. Barrett, Alice V. Bakker, Steven E. Cwirla
Life of this patent
Estimating the term…
Abstract
Peptidyl IL-2Rα ligands and compounds comprising the IL-2Rα ligands are disclosed. The IL-2Rα ligands and compounds such as synthetic monomers, homodimers, or heteromers and recombinant fusion proteins comprising the IL-2Rα ligands can be used as targeting or imaging agents, as diagnostics or to treat cancers and autoimmune diseases.
Claims20
An IL-2Rα ligand, wherein the IL-2Rα ligand comprises an amino acid sequence of Formula (20a) (SEQ ID NO:
- 235) or Formula (20b) (SEQ ID NO:
- 236), wherein the IL-2Rα ligand binds to the human IL-2Rα subunit with an IC50 of less than 100 μM:
- -X3-X4-X5-X6-X7-X8-X9-X10-X11-X12- (20a)
- -X1-C-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12-C-X14- (20b)
- wherein,
- X1 is W;
- X2 is C;
- X3 is selected from F, I, L, M, V, W, and Y;
- X4 is G;
- X5 is Q;
- X6 is P;
- X7 is L;
- X8 is selected from F, I, L, M, V, W, and Y;
- X9 is R;
- X10 is selected from H, N, Q, F, I, L, M, V, W, and Y;
- X11 is G;
- X12 is S;
- X13 is C;
- and
- X14 is K.
17 more elements
An IL-2Rα ligand, wherein the IL-2Rα ligand comprises an amino acid sequence of Formula (20a) (SEQ ID NO:
- 235) or Formula (20b) (SEQ ID NO:
- 236), wherein the IL-2Rα ligand binds to the human IL-2Rα subunit with an IC50 of less than 100 μM:
- -X3-X4-X5-X6-X7-X8-X9-X10-X11-X12- (20a)
- -X1-C-X3-X4-X5-X6-X7-X8-X9-X10-X11-X12-C-X14- (20b)
- wherein,
- X1 is W;
- X2 is C;
- X3 is selected from I and V;
- X4 is G;
- X5 is Q;
- X6 is P;
- X7 is L;
- X8 is selected from F and Y;
- X9 is R;
- X10 is selected from F, H, I, L, M, N, Q, S, T, V, W, and Y;
- X11 is G;
- X12 is S;
- X13 is C;
- and
- X14 is K.
17 more elements
Dependencies are inferred from the claim text.