Amino deprotection using 3-(diethylamino)propylamine
AssigneesAlma Mater Studiorum - Università di Bologna, Fresenius Kabi Ipsum S.R.L.
InventorsGiulia Martelli, Paolo Cantelmi, Alessandra Tolomelli, Chiara Palladino, Lucia Ferrazzano, Walter Cabri, Marco Macis, Angelo Viola, Antonio Ricci
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Abstract
The invention provides a method for the cleavage of Fmoc group characterized by using a solution comprising 3-(diethylamino)propylamine. In particular, it provides a method for the preparation of peptides in solid phase wherein Fmoc protected amino acids are used and the Fmoc group is cleaved by a solution comprising 3-(diethylamino)propylamine.
Claims14
A method for cleaving Fmoc from one or more Fmoc protected amino groups, wherein the method comprises a step of contacting the one or more Fmoc protected amino groups with a solution comprising 3-(diethylamino)propylamine (DEAPA).
A method for the preparation of a peptide by Fmoc-based solid phase peptide synthesis, wherein the method comprises a step of contacting the one or more Fmoc protected amino groups with a solution comprising 3-(diethylamino)propylamine (DEAPA), thereby cleaving the Fmoc from the one or more Fmoc protected amino groups.
Dependencies are inferred from the claim text.