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US 11,691,975 B2Granted
MAGL inhibitors
AssigneeH. Lundbecka/S
InventorsCheryl A. Grice, Daniel J. Buzard, Michael B. Shaghafi
Life of this patent
Estimating the term…
Abstract
Provided herein are spirocyclic and fused bicyclic carbamates and pharmaceutical compositions comprising said compounds. The subject compounds and compositions are useful as modulators of MAGL. Furthermore, the subject compounds and compositions are useful for the treatment of pain.
Claims20
A method of treating pain in a patient in need thereof, comprising administering to the patient a therapeutically effective amount of a compound of Formula (I):
- or a pharmaceutically acceptable salt thereof, wherein:
- is
- X is —O—, —S—, —SO2—, —N(R3)—, or —CH2—;
- Y is —O— or —N(R7)—;
- R1 is —(CR4R5)m—R6, —(CR4R5)p—Y—(CR4R5)q—R6, or —(CR4R5)t—C3-6 cycloalkyl-R6;
- each R2 is independently selected from halogen, —CN, C1-6 alkyl, C1-6 haloalkyl, —C1-6 alkyl(heterocycloalkyl), —OR17, and —C(O)NR18R19;
- R3 is H or C1-6alkyl;
- each R4 and R5 is each independently selected from H, F, and C1-6alkyl;
- or R4 and R5, together with the carbon to which they are attached, form a C3-6 cycloalkyl ring;
- R6 is —CO2R9, —C(O)R10, or —C(O)O—(CR12R13)—OC(O)R11;
- R7 is H, C1-6 alkyl, or —SO2R8;
- R8 is C1-6 alkyl;
- R9 is H or C1-6 alkyl;
- R10 is C1-6 alkyl or —NHSO2R21;
- R11 is C1-6 alkyl or C1-6alkoxy;
- R12 and R13 is each independently H or C1-6 alkyl;
- each R17 is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, aminoalkyl, cycloalkyl, —C1-6 alkyl(heterocycloalkyl), —C1-6 alkyl-C(O)(heterocycloalkyl), optionally substituted heterocycloalkyl, optionally substituted aryl, and optionally substituted heteroaryl;
- each R18 and R19 is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, cycloalkyl, aryl, and heteroaryl;
- or R18 and R19, together with the nitrogen to which they are attached, form a heterocycloalkyl ring optionally substituted with one, two, or three R20;
- each R20 is independently selected from halogen, C1-6 alkyl, C1-6 haloalkyl, oxo, —CN, and C3-6 cycloalkyl;
- R21 is C1-6 alkyl;
- m is 1, 2, 3 or 4;
- n is 0, 1, 2, 3, or 4;
- p is 2, 3, or 4;
- q is 1, 2, or 3;
- and
- t is 0, 1, or 2.
24 more elements
Dependencies are inferred from the claim text.