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US 11,691,972 B2Granted
Compounds for targeted degradation of BRD9
AssigneeC4 Therapeutics, Inc.
InventorsChristopher G. Nasveschuk, Rhamy Zeid, Ning Yin, Katrina L. Jackson, Gesine Kerstin Veits, Moses Moustakim, Jeremy L. Yap
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Abstract
A BRD9 protein degrading compound of structure or a pharmaceutically acceptable salt thereof is provided for the treatment of a disorder mediated by BRD9, including but not limited to abnormal cellular proliferation including cancer.
Claims10
A compound of Formula:
- or a pharmaceutically acceptable salt thereof;
- wherein:
- Q1 is independently at each occurrence selected from the group consisting of NH, N(alkyl), N(haloalkyl), CH2, O, and S;
- X3 is N, CH, or CR3;
- X10 is C(R7)2, C(O), or O;
- X11 is heterocycle optionally substituted with 1, 2, or 3 groups independently selected from R3;
- X16 is selected from the group consisting of N, CH, and CR4;
- R3 is independently at each occurrence selected from the group consisting of hydrogen, hydroxyl, alkoxy, C1-C4alkyl, C1-C4haloalkyl, cycloalkyl, fluorine, chlorine, bromine, and iodine;
- each R4 is independently selected from the group consisting of hydrogen, aryl, heteroaryl, C1-C4alkoxy, C1-C4haloalkyl, C1-C4haloalkoxy, C1-C4alkyl, fluorine, chlorine, bromine, and iodine;
- each R7 is independently hydrogen, methyl, or ethyl;
- and
- R8 is hydrogen, C1-C4alkyl, alkenyl, alkynyl, haloalkyl, or cycloalkyl.
9 more elements
A compound of structure
- or a pharmaceutically acceptable salt thereof.
A compound of structure:
A compound of structure:
Dependencies are inferred from the claim text.